Canadian epigenetics jobs and training opportunities

If you have a Canadian job or training opportunity you'd like to list on this site and/or on our Twitter feed, please contact us at info@epigenomes.ca. This is a free service.

For international epigenetics and epigenomics job listings, please see the IHEC website.

 

Postdoctoral Positions in Computational Biology and Computational Biophysics in the Panchenko lab I Queen's University

Postdoctoral positions in computational biology and computational biophysics are available in the Panchenko laboratory located at Queen’s University School of Medicine in Kingston and affiliated with the Ontario Institute for Cancer Research (OICR) in Toronto, Canada. Our team investigates epigenetic factors, including DNA/histone covalent modifications and histone variants, that may contribute to cancer etiology. Specifically, we study how the diverse set of nucleosome and chromatin alterations is connected to cancer mutagenesis, modulates the recruitment of specific chromatin components with spatiotemporal precision and influences the stability, dynamics and accessibility of DNA. Our objective requires designing new computational and hybrid methods that use experimental data and involve machine learning, molecular modeling and molecular dynamics simulations. Please see our published work at  https://www.ncbi.nlm.nih.gov/CBBresearch/Panchenko/publications.html.

The Panchenko lab is moving from the National Institutes of Health (NIH), USA in July 2019.

Postdoctoral fellows will be subjected to a rich research environment with various opportunities for close collaboration with computational and experimental labs at the top research facilities in Canada and USA including Queen’s University, Center for Advanced Computing at Queen’s, OICR and National Institutes of Health.

Qualifications:

For Postdoctoral positions in computational biology: statistical methods, machine learning, practical experience working with large-scale data sets.

For Postdoctoral positions in computational biophysics: molecular modeling and molecular dynamics simulations, structural bioinformatics.

We expect the candidates to be happy to work in a collaborative and inter-disciplinary environment.

Qualified candidates should send their CV and the names and contact information for three referees to Dr Anna Panchenko (anna.panch2014@gmail.com).

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Queen’s University is recognized nationally and internationally for the quality of its research, graduate, and undergraduate programs, and is ranked as a research leader among Canadian post-secondary institutions. The university is located in historic Kingston, on the shore of Lake Ontario, with easy access to Montreal, Toronto, Ottawa & the U.S. border. OICR is located in downtown Toronto and focuses its research efforts toward the clinic to accelerate translational cancer research in Ontario and worldwide.

Location: Kingston, ON, Canada
Lab: The Panchenko lab
Posting Date: 2019-05-29
Closing date: not stated 
 

Postdoctoral Fellow in Developmental Epigenetics in the Ramalho-Santos lab I The Lunenfeld-Tanenbaum Research Institute 

Position Summary:

Applications are invited for the position of postdoctoral fellow at the Lunenfeld-Tanenbaum Research Institute (LTRI). The successful candidate will join the group led by Dr. Ramalho-Santos in the field of mammalian developmental epigenetics. The LTRI is an internationally-renowned biomedical research institute affiliated with the University of Toronto, one of the top 20 universities in the world. The LTRI has major strengths in Systems Biology and Developmental and Stem Cell Biology. The lab is supported by stellar core facilities for sequencing, proteomics, imaging, flow cytometry and metabolomics. The LTRI has one of the best academic mouse facility in North America.

The lab is interested in the epigenetic control systems that govern early mammalian development and pluripotent stem cell biology. Topics include the open chromatin state of pluripotent stem cells, hypertranscription, developmental pausing, roles of transposons in stem cell biology and epigenetic modulation of developmental trajectories by environmental factors.

Several postdoctoral fellow positions are immediately available.

Education and Experiences:

A doctoral degree in a biomedical research field is required. Preference will be given to candidates with experience and a publication record in:

Developmental Biology, Fertilization, Pre-Implantation Development, Pluripotency, Germline Development, Embryonic and Adult Stem Cell Biology, DNA Methylation, Chromatin Biology, Non-Coding RNAs, Epigenomics, Transgenerational Epigenetic Inheritance, Functional Genomics, Genome Editing, Transposon Biology, Nuclear Dynamics, Bioinformatics.

How to Apply:

Please send curriculum vitae, cover letter explaining expertise and the candidate’s interests fits with the lab’s, and the contact information of three references to mrsantos@lunenfeld.ca.

Position open until filled. We appreciate all expressed interests in this position. Only those candidates short listed for interview will be contacted.

Location: Toronto, ON, Canada
Posting Date: 2019-03-27
Closing date: not stated 
 

Postdoctoral Position in the Hemberger lab I The University of Calgary

Area: Developmental Epigenetics and Stem Cell Biology
Duration: 1 year in the first instance with funding available for up to three years 
Start date: as soon as possible
Salary: $50,000 per year plus benefits   

Dr. Myriam Hemberger and Dr. Wendy Dean in the Department of Biochemistry & Molecular Biology, Cumming School of Medicine, and the Alberta Children’s Hospital Research Institute, at the University of Calgary are accepting applications for a postdoctoral fellow in Developmental Epigenetics and Stem Cell Biology.

Job Description:

We are looking for a talented and highly motivated Postdoctoral Fellow in the area of reproductive biology with particular focus on developmental epigenetics and stem cell biology. The successful candidate will work with Drs. Myriam Hemberger and Wendy Dean to advance our understanding of fundamental processes during early development in health and disease. We are using cutting-edge stem cell tools, combined with state-of-the-art transcriptomics and epigenomics methods to gain insights into gene function in placentation and embryogenesis. The core priority of this project is to investigate the impact of specific mutations on cellular differentiation and developmental outcomes using stem cell models including embryonic (ESCs), induced pluripotent (iPSCs) and trophoblast (TSCs) stem cells in advanced 2-dimensional and 3-dimensional culture systems (e.g., gastruloids, organoids).

The candidate will join an interactive research environment set within a newly refurbished open-plan laboratory space. State-of-the-art computational, imaging and molecular biology facilities are available. The candidate will also benefit from a thriving research environment and engage with a broad range of investigators with expertise in stem cell and cancer epigenetics, bioengineering and regenerative medicine.

Qualifications:

We seek a talented, highly motivated postdoc to work on a funded project, available immediately.

The successful candidate will hold and/or be able to demonstrate:

  • PhD degree obtained within the last 3-years in developmental biology, epigenetics, stem cell biology or a related subject area
  • Proven track record in academic research
  • An excellent understanding of stem cell biology in the context of early mammalian development, and a solid background in mouse and human genetics
  • Hands-on expertise in handling and manipulating mouse and/or human ESCs, iPSCs and/or TSCs, ideally including the use of CRISPR technology
  • High-level expertise in chromatin biology, including performing chromatin immunoprecipitation assays and in the generation of Next-Generation sequencing libraries (ChIP-seq, RNA-seq, ATAC-seq etc)
  • Significant bioinformatic knowledge for analysis of high-throughput datasets is highly desirable

Application details:  

For further information on this position, please contact myriam.hemberger@ucalgary.ca or wendy.dean@ucalgary.ca. Interested applicants should apply by email to the above investigators and include a Cover Letter describing their motivation for this position, a detailed CV, a description of their research expertise and the names and contact details of 3 referees.

Location: Calgary, AB, Canada
Posting Date: 2019-03-11
Closing date: not stated 
 

Postdoctoral Position in the Weksberg lab I The Hospital for Sick Children (SickKids) Research Institute 

The laboratory of Dr. Rosanna Weksberg at The Hospital for Sick Children (SickKids) Research Institute is seeking a postdoctoral research fellow. Work in the lab focuses on clinical epigenetics, with many projects investigating the role of DNA methylation in various neurodevelopmental disorders. The fellow will take the lead on several projects, including the role of DNA methylation in ASD/ADHD/OCD and projects on other rare neurodevelopmental disorders. The fellow will work closely with several other fellows, research assistants, and technicians in the lab. A successful candidate will be highly motivated, and be able to work independently in experimental design, data analysis, and manuscript preparation. It is expected that the candidate will generate several high-impact publications during the tenure of the fellowship. The SickKids Research Institute is a world-class research environment, providing many opportunities for additional training and academic enrichment. Dr. Weksberg is also cross-appointed to the Department of Clinical and Metabolic Genetics, allowing additional opportunities for the candidate for learning/collaboration in clinical genetics. Candidates having their own funding are preferred. The candidate may start the position as soon as possible.

Specifically, the candidate will:

  • Use established bioinformatics pipelines for analysis of DNA methylation microarray data
  • Lead the analysis, interpretation, and publication of several distinct projects in clinical epigenetics
  • Participate in grant writing
  • Present at local and international conferences
  • Collaborate closely with genetic counsellors and clinicians at SickKids and around the world

Required Qualifications:

  • PhD in molecular biology, genetics, computational biology or related field
  • Record of high-quality research output
  • Understanding of microarray and sequencing data analysis
  • Excellent written and oral communication skills in English
  • Use of R programing language
  • Excellent references

To apply send a cover letter describing career goals/interests and a full CV to Sean Rampersad (sean.rampersad@sickkids.ca).

Location: Toronto, ON, Canada
Posting Date: 2019-03-08
Closing date: not stated 
 

Postdoctoral Position in Cell and Chemical Biology I University of Toronto

Are you interested in drug discovery and the translation of biological knowledge? Want to work in a diverse, fast-paced, multidisciplinary environment that brings together drug
design, structural biology, protein function, cell biology, and disease mechanisms?
 
Structural Genomics Consortium seeks an ambitious and scientifically-creative cell and molecular biologist to work in an highly collaborative environment with both academic and industry partners. The successful candidate will be involved in the discovery and validation of chemical probes (small molecule drug-like inhibitors) that target epigenetic regulatory proteins and ubiquitin-mediated signaling pathways. Utilizing both chemical and molecular biology, the research will also involve the functional and mechanistic characterization of probe targets with respect to their involvement in cell biology and disease.
 
Qualifications:
  • Strong experimental skills in: molecular biology, protein, RNA and DNA analysis.
  • Experience in cellular and phenotypic screening, cell culture, image analysis, bioinformatics, and/or proteomic/(epi)genomic analyses.
  • Experience in cancer or immune cell biology is an asset.
  • Experience working in multidisciplinary environment.
  • Strong organizational, team and communication skills.
  • PhD obtained within the last 5 years.
Interested candidates please send CV and cover letter to Cheryl.Arrowsmith@uhnresearch.ca
 
Recent selected publications relating to the project:
  • Scheer S et al A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling. Nature Communications 2018 accepted
  • Bromberg K et al. The novel SUV4-20 inhibitor A-196 verifies a role for epigenetics in the maintenance of genomic integrity. Nature Chemical Biology, 13:317-324 (2017)
  • He Y et al. Targeting the PRC2 complex through a novel protein-protein interaction inhibitor of EED, Nature Chemical Biology, 13:389-395 (2017)
  • Grebien F et al. Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia. Nature Chemical Biology 11:571-8 (2015)
  • Arrowsmith et al. The promise and peril of chemical probes Nature Chemical Biology 2015 11:536-41.
The SGC is a not for profit, public-private partnership working with academia and nine pharmaceutical companies to carry out open access science relevant to human health and drug discovery. http://www.thesgc.org, http://www.thesgc.org/scientists/epigenetics
The University of Toronto and its affiliated hospital research institutes comprise one of the largest and most productive centers of biomedical research in North America. Located in vibrant downtown Toronto, the University provides an outstanding opportunity for scientific research, and career development.
 
Location: Toronto, ON, Canada
Posting Date: 2019-02-08
Closing date: not stated 
 

Postdoctoral Scholar: Human Social and Population Epigenetics | University of British Columbia & BC Children's Hospital Research Institute

Seeking a highly motivated and ambitious recent PhD graduate to work on various projects related to understanding the causes and consequences of variation in epigenetic marks across human populations. This is an ideal position for applicants who wish to develop the skills required to launch an independent research programme.  The successful applicant will have opportunities to develop their own research directions while also leading and contributing to a number of existing funded projects. These include population cohort studies that focus on the genomic embedding of early-life experiences in relationship to development and health across the lifespan. This work involves the acquisition of high-dimension datasets for genotyping, DNA methylation and mRNA expression and their integrative analysis with phenotype and environmental exposures. The ideal applicant will possess a curiosity and passion for science and a talent for independent research, which should be supported by a strong publication record with at least two first author publications in respected journals. Extensive knowledge of statistical genomics and/or epigenetics / gene regulation is required, and experience with bioinformatics is preferred.

Location: Vancouver, BC, Canada
Lab: Kobor Lab
Posting Date: 2019-01-21
Closing date: not stated 
Contact: msk@bcchr.ca
 

Research Technician: Statistical and Bioinformatics Approaches to Human Epigenetics | University of British Columbia & BC Children's Hospital Research Institute

Seeking a highly motivated Research Technician. The successful applicant will perform statistical analyses of high-throughput epigenomics and genotyping data to facilitate the interpretation of associations between molecular data with environment, stress and disease. The position will provide opportunities to lead projects toward publication and attend national and international conferences. The lab's research comprises wet lab and bioinformatics approaches to understanding epigenetics, from molecular analysis in model organisms to population-scale studies of human epigenetic variation. The successful applicant will take part in multiple collaborations with local, national, and international groups on diverse projects related to children's mental and physical health.

Location: Vancouver, BC, Canada
Lab: Kobor Lab
Posting Date: 2019-01-21
Closing date: not stated 
Contact: msk@bcchr.ca
 

Science and Grant Writer: Social Exposome and Epigenetics | University of British Columbia & BC Children's Hospital Research Institute

Job ID 32328. There are two components to this position, 0.5 FTE will be as a Research Manager responsible for managing the activities of the UBC Social Exposome Research Cluster, which is funded by the UBC Grants for Catalyzing Research Clusters program at UBC. The Cluster is led by Dr. Michael Kobor who is a Professor in the Department of Medical Genetics at UBC. In addition, 0.5 FTE will be as a Grant Writer to develop proposals and funding applications for various projects in Dr. Kobor's Social Epigenetics laboratory, which is located at the BC Children's Hospital Research Institute (BCCHR) where the incumbent will be based.

Major responsibilities for the Research Manager position include but are not limited to: organizing and coordinating meetings, workshops, and seminars; identifying new directions for research collaborations and projects between the investigators involved in the Social Exposome Research Cluster; identifying funding opportunities and writing grant proposals; identifying and liaising with community and not-for-profit partner organizations; and operational tasks related to the Cluster, including managing the budget and submitting progress reports.

Major responsibilities for the Grant Writer position include: writing, identifying, developing, and preparing research grant and other academic proposals, letters of intent, background documentation, research program rationales, ethics submissions, budgets and budget justifications, and other documents.

Location: Vancouver, BC, Canada
Lab: Kobor Lab
Posting Date: 2019-01-21
Closing date: not stated 
Contact: Apply through website
 

Graduate Students in the Jones lab | University of Manitoba

In the Jones lab, we are interested in how the epigenome serves as a kind of cellular memory. As the video below shows, sometimes during a sensitive period of development, an environmental exposure can change the epigenome. That change might then go on to influence possible health outcomes. 

The primary hypothesis we test is that environments in utero and in early life can leave behind differences or changes in the epigenome. These changes have been observed in human populations, but we don't know what they do or whether they have long term outcomes. Our research looks at the molecular links between these early life environments, epigenetic changes, and long term health outcomes.

Location: Winnipeg, MB, Canada
Lab: Jones Lab
Posting date: 2019-01-21
Closing date: not stated
 

Post-doctoral Fellowship in the Brand lab I Ottawa Hospital Research Institute 

The Ottawa Hospital: Inspired by research. Driven by compassion
The Ottawa Hospital Research Institute (OHRI) is the research arm of The Ottawa Hospital and an affiliated institute of the University of Ottawa. With more than 1,700 scientists, clinician investigators, trainees and staff, and total revenues of more than $100 million, we are one of the foremost Canadian hospital-based research institutes. We are investigating virtually every major disease and condition, with a focus on answering important health questions and translating our findings into benefits for patients and society. 
 
Brief Job Description:
A 3-year postdoctoral fellowship is available to examine epigenetic changes in response to alpha-radiation in the blood of humans chronically exposed to radon. This study is part of a project aimed at understanding the effects of radon exposure on cancer susceptibility in Canada.  The project will be performed in collaboration between Dr. Richard Richardson’s lab at the Canadian Nuclear Laboratories (CNL) in Chalk River (http://www.cnl.ca/en/home/default.aspx), and Dr. Marjorie Brand’s lab at the Sprott Center for Stem Cell Research at the OHRI (http://marjoriebrandlab.com/). The postdoctoral fellow will be based mostly at the OHRI with frequent visits to the CNL.

The Sprott Center is a premier research center in Canada. Located at the OHRI, the Center offers outstanding on-site core facilities (CyTOF, 10x Chromium, Nanopore RNA sequencing, mass spectrometry, microscopy) (http://www.ohri.ca/FacilitiesAndServices/) for advanced molecular and cellular studies. Advanced computational biology support is provided both on-site through the Ottawa Bioinformatics Core and through internal and external collaborations. 

Requirements (Education/Experience):
We are seeking a highly motivated, self-driven individual, interested in developing and managing a research project on epigenetic modifications (particularly DNA methylation) in blood cells of human donors chronically exposed to radon.  Candidates should be near completion or being within two years of completing a PhD in cellular and molecular biology or a similar area.

Candidates should have at least one first (or co-first) author manuscript, published or under consideration at an international scientific journal. Previous experience studying DNA methylation (wet lab and computational) would be an asset. Candidates must be a Canadian citizen or be a permanent resident and have lived in Canada for at least 5 years.

Comments to applicant:
Interested individuals should send a full CV with a 1-page paragraph describing their motivation to join the lab as well their future career goals. Applications should be sent as a single pdf by email to Sandy Martino at  smartino@ohri.ca.

Location: Ottawa, ON

Lab: Brand Lab

Posted: 2019-01-04

Closing Date: 2019-01-18

Contact:  smartino@ohri.ca

 


Post-doctoral Fellowship in Cancer Epigenomics | University of British Columbia

We are seeking an innovative postdoctoral fellow who is interested in applying his/her expertise towards understanding the role of epigenetic dysfunction in human disease. The successful candidate will be embedded within a team of experimental and computational biologists and have access to a state-of-the-science epigenomic mapping pipeline and epigenomic datasets from primary cancer types and models. As part of national and international cancer research initiatives, s/he will direct a research program to uncover the pathogenic mechanisms underlying recurrent genetic lesions in specific cancer types with an ultimate goal of identifying and testing therapeutic targets.

To learn more about research in the Hirst Lab, please visit: http://hirstlab.msl.ubc.ca/ 

To learn more about pursuing a postdoctoral fellowship at the University of British Columbia, please visit: https://www.postdocs.ubc.ca

Qualifications: Exceptional recent PhD graduates with expertise in functional genomics and a desire to build a world-class independent research program are encouraged to apply

How to apply: Please  send CV and cover letter outlining career goals to swang@bcgsc.ca

Location: Vancouver, BC

Lab: Hirst Lab

Posted: 2018-11-13

Closing Date: not stated

Contact:  swang@bcgsc.ca

 


Graduate Students in Cancer Epigenomics | University of British Columbia

We are looking for innovative students who are interested in pursuing a PhD in the Epigenomics Laboratory at the University of British Columbia. Our research applies cutting edge experimental and computational methodologies to develop and test hypothesis of functional genomic mechanisms driving rare and common forms of cancer. The successful candidate will be embedded within a team of experimental and computational biologists and have access to a state-of-the-science epigenomic mapping pipeline and epigenomic datasets from primary cancer types and models. The applicant will be expected to work independently and collaboratively with clinical and other domain experts with an ultimate goal of improving outcomes for cancer patients. Students can choose from either a combined experimental and computational program or an exclusively computational track.

To learn more about research in the Hirst Lab, please visit: http://hirstlab.msl.ubc.ca/ 

To learn more about pursuing a PhD degree at the University of British Columbia, please visit: https://www.grad.ubc.ca

Qualifications: Exceptional students with demonstrated communication skills and undergraduate research experience. Students seeking an exclusively computational PhD must have unix shell scripting and statistical training.

How to apply: Please  send CV and cover letter outlining career goals to swang@bcgsc.ca

Location: Vancouver, BC

Lab: Hirst Lab

Posted: 2018-11-13

Closing Date: not stated

Contact:  swang@bcgsc.ca

 


Graduate studies in gene expression regulation, Robert lab in the IRCM, a research center affiliated with Université de Montréal

Research topic:

Building a high-resolution map of protein interactions along the RNA polymerase II CTD using site-specific BPA crosslinking in living cells

Project summary:

RNA polymerase II, the enzyme responsible for the transcription of pre-mRNA and most non-coding RNAs in eukaryotes, contains a carboxy-terminal domain (CTD) made of repetitions of a heptapeptide having YSPTSPS as consensus sequence. This peptide is repeated 26 times in yeast and 52 times in human. The tyrosine (Tyr1), threonine (Thr4) and all three serines (Ser2, 5 and 7) of each repetition are subject to a cycle of phosphorylation and dephosphorylation during transcription, creating an astronomical number of possible combinatorial phosphorylation states that are thought to constitute a “CTD code” read by CTD-binding proteins. Long-standing questions in the field are whether individual repeats have specific functions and whether the “CTD proteome” assembles in an organized structure or consists of very dynamic low affinity and high valency interactions? In this project, we propose to use BPA crosslinking to create a high-resolution map of protein binding along the CTD in living cells as a way to molecularly decipher the functions of different CTD repeats or regions.

Summary of responsibilities:
This project takes advantage of clever manipulations of the genetic code in Saccharomyces cerevisiae to introduce a modified amino acid (BPA) that can be induced to crosslink neighboring proteins in specific regions of the CTD in living cells. This approach will be used in combination with state-of-the-art proteomic technologies and standard biochemistry and molecular biology methods. The student/postdoc will be in charge of executing and analysing the vast majority of the experiments for the project and will be assisted during his/her training by Dr. Robert and senior members of the lab. The IRCM has several core laboratories with expertise that will enhance the training experience of the candidate.

Recent selected publications:

  • Collin P, Jeronimo C, Poitras C, Robert F. (2018) RNA Polymerase II CTD Tyrosine 1 is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway. Under review.
  • Jeronimo C, Collin P, Robert F. (2016) The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain. J Mol Biol. 2016 Jun 19;428(12):2607-2622.
  • Bataille AR, Jeronimo C, Jacques PÉ, Laramée L, Fortin MÈ, Forest A, Bergeron M, Hanes SD, Robert F. (2012) A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. Mol Cell. 2012 Jan 27;45(2):158-70.

Job requirements:
We seek a highly motivated individual with a genuine interest in understanding the mechanistic aspects of molecular processes. A background in molecular biology and/or biochemistry is mandatory. Knowledge in bioinformatics, computer programming or statistics are assets but not mandatory. Only candidates with very good academic track records will be considered.

Location: Montreal, QC. At IRCM, a research center affiliated with Université de Montréal. Laboratory of Chromatin and Genomic Expression, led by Dr. François Robert. www.robertlab.org

Posted: 2018-10-31

Starting date: As soon as possible

Closing date: not stated

Contact: Send your candidacy by e-mail to: Francois Robert. francois.robert@ircm.qc.ca

 


Graduate studies in gene expression regulation, Robert lab in the IRCM, a research center affiliated with Université de Montréal

Research topic:

The use of long-read sequencing for the identification of protein complexes footprints on the chromatin of individual cells

Project summary:

Binding of proteins to specific sites on DNA is a fundamental aspect of nuclear processes such as gene expression, DNA replication, DNA repair and others. A number of techniques such as ChIP-seq, DNase-seq, FAIRE-seq and others are used to map protein-DNA interactions at the genome-wide scale in living cells. The readout of these methods, however, comes from averaging bulk measurements from a population of cells. These methods are therefore unable to reveal the cell-to-cell heterogeneity of protein-DNA interactions and provide very limited information about the relationship between neighboring interactions on the same molecule. The primary goal of the proposed project is to overcome the above-mentioned limitations by developing an advanced technique to generate high-resolution long footprints of protein-DNA binding at single-molecule level in living cells. The methods to be developed will take advantage of a recent sequencing technique called SMRT-sequencing from PacBio.

Summary of responsibilities:
This project combines the use of state-of-the-art functional genomic technologies with standard biochemistry and molecular biology in Saccharomyces cerevisiae. The student/postdoc will be in charge of executing and analysing the vast majority of the experiments for the project and will be assisted during his/her training by Dr. Robert and senior members of the lab. The IRCM has several core laboratories with expertise that will enhance the training experience of the candidate.

Recent selected publications:

  • Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F. (2017) Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes. Nucleic Acids Res. 2017 Jun 20;45(11):6417-6426.
  • Jeronimo C, Langelier M-F, Bataille AR, Pascal JM, Pugh BF, Robert F. (2016) Tail and Kinase modules differently regulate core Mediator recruitment and function in vivo. Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20.
  • Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F. (2015) The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol Cell. 2015 Jun 18;58(6):1113-23.

Job requirements:
We seek a highly motivated individual with a genuine interest in understanding the mechanistic aspects of molecular processes. A background in molecular biology and/or biochemistry is mandatory. Knowledge in bioinformatics, computer programming or statistics are assets but not mandatory. Only candidates with very good academic track records will be considered.

Location: Montreal, QC. At IRCM, a research center affiliated with Université de Montréal. Laboratory of Chromatin and Genomic Expression, led by Dr. François Robert. www.robertlab.org 

Posted: 2018-10-31

Starting date: As soon as possible

Closing date: not stated

Contact: Send your candidacy by e-mail to: Francois Robert. francois.robert@ircm.qc.ca

 


Postdoctoral Research Fellow in the Jabado lab, Research Institute of the McGill University Health Centre

A full-time position for a postdoctoral fellow is available in the research laboratory of Dr. Nada Jabado, at the Research Institute of McGill University Health Centre in Montreal, Canada. Research in the Jabado lab focuses on the investigation of pediatric brain tumours, specifically high-grade gliomas that are epigenetically dysregulated, such as those carrying histone 3 mutations. The lab uses diverse approaches to this end, including the genomic and epigenomic profiling of patient tumours, mouse xenografts and transgenic models, cell culture studies on primary and manipulated cell lines and drug studies on mouse models and cultured cells to test potential treatment agents. We use many state-of-the-art genomic/epigenomic techniques, such as ChIP-seq, Hi-C and single-cell RNA-seq, in addition to routine molecular and cell biology techniques like PCR, cloning and Western Blots. Dr. Jabado has numerous collaborations with research groups across the world that allow us to gain access to other specialized techniques. For more information on the Jabado lab, please visit our website at https://www.jabadolab.com/.

Applicants must have a PhD in a relevant life sciences field with experience in cell and molecular biology techniques including tissue culture. Experience in CRISPR/Cas9 genome editing and epigenomic techniques such as ChIP-seq is highly desirable. Bioinformatics skills required for analyzing genomic and epigenomic data would be a great asset. Ideally, the successful candidate will have the ability to straddle the wet-bench and bioinformatics components of work conducted in the Jabado lab, however candidates with experience in either may apply. Above all, we are looking for someone curious, highly independent and eager to use research to help improve the currently bleak prospects of children with high-grade pediatric brain tumours.

To apply, please send your CV and a cover letter to: njabadolab at gmail dot com

Location: The Research Institute of McGill University Health Centre in Montreal, QC.

Posted: 2018-10-15

Closing date: not stated

Contact: njabadolab at gmail dot com

 


Bioinformatics Scientist - The Children's Hospital Research Institute of Manitoba

The successful candidate will provide bioinformatics service for a multidisciplinary team of scientists. The work will apply bioinformatics data analysis under the supervision of a Scientific Oversight Committee. The work will focus on research questions relevant to maternal and child health that involves providing bioinformatics support to multidisciplinary researchers ranging from senior clinical scientists and basic biomedical scientists to the graduate and post-graduate trainees. The candidate will consult with and train researchers on the development of bioinformatics methods and data analysis pipelines to process large datasets from Next Generation Sequencing, proteomics and metabolomics and assist in the biological interpretation of the data.

The Department of Pediatrics and Child Health is one of Manitoba’s largest academic clinical departments, with diverse and significant commitment to excellence in clinical, basic and translational research, post-graduate clinical and research training, and graduate student training. Support for research and research training are facilitated through close partnership with the Children’s Hospital Research Institute of Manitoba (CHRIM), as well as with academic departments in the Rady Faculty of Health Sciences with programs accredited by the Faculty of Graduate Studies. CHRIM provides, within 32,000ft2 of new wet lab and animal research space, laboratory and office space for investigators and their team, multi-user research infrastructure and core facilities for cell and molecular biology research, as well as small animal lung function and metabolic testing. CHRIM has a substantial annual equipment budget and is home to a sophisticated Next Generation Sequencing core facility.

Responsibilities

  • Data quality check and data normalization
  • Data annotation and pathway analyses
  • Assist in developing, devising or improving existing bioinformatics methods, practices and procedures
  • The individual should be capable to work with human and animal model data
  • The individual will also be responsible for the integration of these large data sets for systems biology level of “mixomics” analyses

Candidates must have:

  • MSc or higher with experience in health related research required

Experience

  • Candidates should have a strong background in bioinformatics or computational biology, and be capable of conducting a range of statistical analyses
  • A strong background with unix/linux tools and administration is required
  • Previous experience with the analysis of large data sets in a health related field (e.g. proteomics, metabolomics or NGS) is mandatory
  • Advance knowledge of relevant platforms and data types (e.g. FASTQ, BAM, VCF, MAF) and related analytical tools is necessary
  • Experience with coding as well as machine learning approaches in R are an asset

Skills & Abilities

  • Ability to work independently and within a dynamic collaborative and multidisciplinary environment
  • Possess excellent communication and organizational skills
  • Ability to meet deadlines and milestones
  • Have a proven track record of productivity
  • Familiarity with biology, molecular biology and computer hardware is an asset
  • Assist in developing, devising or improving existing bioinformatics methods, practices and procedures

Applications should be sent by email to humanresources@chrim.ca

Location: The Children’s Hospital Research Institute of Manitoba, Winnipeg, MB

Posted: 2018-09-13

Closing date: not stated

Contact: humanresources@chrim.ca

 


Postdoctoral Fellow/Research Associate - Hoodless Lab: Vancouver, Canada

A postdoctoral fellowship/research associate position is available in the Hoodless lab based in the BC Cancer Agency Research Centre in Vancouver, Canada. The ideal candidate will have expertise in mouse genetic modelling, embryology, hepatic biology and/or transcription/epigenetics. Candidates must hold a doctoral degree in a relevant field, be looking for a collaborative and dynamic environment, and have a track record of productivity.

The Hoodless lab uses state of the art genomic technologies to explore and gain new insight into classical processes in developmental biology. Using genome-wide analysis of gene expression, transcription factor binding and histone modifications, they investigate regulatory mechanisms in heart and gastrointestinal tract development in the mouse embryo. Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to:

Jordan Cran (jcran@bccrc.ca) with the subject: Postdoctoral Fellow/Research Associate - Hoodless Lab

Location: Vancouver, BC

Lab: Hoodless Lab (link: http://www.terryfoxlab.ca/people-detail/pamela-hoodless/)

Posted: 2018-08-10

Closing date: 2018-10-31

Contact: jcran@bccrc.ca

 


Postdoctoral fellow applied to functional epigenomics : Toronto, Canada

Fully affiliated with the University of Toronto and home to members of the Faculties of Medicine, The Princess Margaret Cancer Centre is part of one of Canada's largest hospital-based research centers. As one of the top five cancer research institutes in North America The Princess Margaret Cancer Centre fosters a rich academic and collegial environment. Combining research excellence with state-of-the-art infrastructure, The Princess Margaret Cancer Centre is investing heavily in strategic research platforms and has developed research capacity in areas such as Epigenomics, Genomics, Proteomics, Clinical Technologies, and Clinical Studies to drive investigations into human biology and health care now and into the future.

As part of The Princess Margaret Cancer Centre Epigenomics program and affiliated with the Ontario Institute for Cancer Research (OICR), Dr. Mathieu Lupien is currently seeking applications for a wet lab and computational postdoctoral fellows applied to functional epigenomics. The work will focus on defining the interplay between epigenomics, metabolomics and/or transcriptional regulation in cancer (breast, prostate or brain (GBM)). The successful candidate will be involved in the generation of omics data (ChIP-seq, ATAC-seq, RNA-seq, whole-genome-seq, etc) and their analysis. More information on research interests and publications from the Lupien lab is available at: www.pmgenomics.ca/lupienlab

Candidates should have a strong background in epigenetics, genomics, metabolomics, computational biology, bioinformatics or biostatistics, hold a doctoral degree in a relevant field, be looking for a collaborative and dynamic environment, and have a track record of productivity and innovation. Prior experience in generating and analyzing omics datasets is an asset but not a requirement. The salary of this yearly renewable position will be established according to institutional guidelines.

Please forward current curriculum vitae including a publication list and names of three references to: mlupien@uhnres.utoronto.ca

We thank all applicants for applying, however, only those selected for an interview will be contacted.

Location: Toronto, ON

Lab: Lupien Lab

Posted: 2018-05-25

Closing Date: 2018-07-01

Contact:  mlupien@uhnres.utoronto.ca

 


Post-doctoral Fellowship in Brain Cancer Epigenomics | University of Calgary

 We are looking for a talented, hard-working, independent and highly motivated individual to join us as a postdoctoral fellow.

The candidate needs to be within one year of their PhD, and have a proven record of peer-reviewed research publications. Experience with molecular techniques and cell culture models is a requirement. Previous work with animal models is preferable.

The successful candidate will have an opportunity to study chromatin biology in the context of brain tumors. She/he will use patient-derived primary cultures and patient-derived xenografts to study molecular determinants of cancer stem cell properties. Single-cell RNA-seq, genomics and epigenomics techniques will be complemented by functional studies of gene function in vitro and in vivo.

Please note that this is a wet lab position, but the successful candidate will have an opportunity to implement computational pipelines that have been standardized in the lab if she/he is so inclined. Computational experience is NOT a requirement for this position.

We have a very competitive salary and benefit package. And the Rockies are less than an hour away, making Calgary a perfect place for the scientist that needs to be immersed in nature to think!

If you are interested in joining us, please email your CV and a cover letter to marco.gallo@ucalgary.ca

Location: Calgary, AB

Lab: Gallo Lab

Posted: 2018-03-09

Closing Date: not stated

Contact:  marco.gallo@ucalgary.ca

 


Bioinformatics Postdoctoral Fellow and Bioinformatics Research Associate | Princess Margaret Cancer Centre

Two funded positions are available in the De Carvalho Lab at Princess Margaret Cancer Centre: Bioinformatics Postdoctoral Fellow and Bioinformatics Research Associate

The focus of the projects are in translational cancer epigenomics, with multiple projects available in Methylome profiling of cancer cells and circulating cell-free DNA ('liquid biopsy') for cancer classification, early detection and disease monitoring; Cancer Epigenetics therapy to target cancer stem cells and to increase anti-tumour immune response. The projects will include epigenomic approachers such as ChIP-seq, ATAC-seq, CUT&RUN, RRBS, WGBS among others and functional approaches such as CRISPR screening.

The research will be conducted at the Princess Margaret Cancer Centre, a research hospital affiliated to the University of Toronto, in one of the most liveable cities in the world.

The ideal candidate should have:

  • PhD in computational biology, bioinformatics, biostatistics, cancer biology, epigenomics, genomics, or a related field;

  • Experience with epigenomics and transcriptomics data analysis from ChIP-seq, ATAC-seq, RRBS, WGBS, RNA-seq experiments;

  • Experience with large data-sets (e.g., ENCODE, TCGA, GTEx);

  • Experience with Machine Learning/Deep Learning applied to biology or oncology;

  • Proficiency in general-purpose programming language and scientific data processing ecosystems (e.g. R, R-studio);

  • Good publication record

Location: Toronto, ON

Lab: De Carvalho Lab

Posted: 2018-01-03

Closing Date: not stated

Contact: Those interested in the position described should submit full CV and cover letter to Dr. Daniel D. De Carvalho: epigenome.search@gmail.com

 


Bioinformatician | BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre

We are seeking an enthusiastic and self-motivated bioinformatician, with excellent communication skills, to work on integrative and comprehensive analyses of cancer genome/transcriptome/epigenome sequence data. The successful applicant will have a proven track record of publications in scientific journals, be fluent in R and at least one of the following programming languages: Perl/Python/C++/Java, and is expected to have strong skills in the field of one or more of the following: genomics, cancer biology and statistics. Knowledge of and experience with large-scale cancer genome data sets (such as TCGA) is particularly desired. A PhD or equivalent is desirable, although qualified applicants with a research-based masters degree may be considered.

The successful applicant for this position will be based within the laboratory of Dr. Marco Marra in Canada's Michael Smith Genome Sciences Centre (GSC) at the BC Cancer Agency. Dr. Marra is the director of the GSC, a world-class genome institute that generates sequence data for hundreds of cancer samples each year, and has state-of-the-art computational power, including a 8000 node computing cluster and >10 large CPU and RAM machines for data analysis. As such, the successful applicant will have the opportunity to mine large scale cancer genome data sets to address pertinent questions concerning cancer pathogenesis and treatment resistance in adults and children. 

The Marra Lab is a successful multi-disciplinary team of cancer researchers, and is filled with passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research in the lab is conducted in close collaboration with local and international scientists and clinicians, and thus will also provide the successful candidate with opportunities to learn from a large network of talented professionals.

Main Duties and Responsibilities

  • To survey the relevant literature to identify pertinent scientific questions to be addressed, and relevant techniques to employ for this purpose.

  • To apply state-of-the-art bioinformatics methods to the analysis of cancer sequence data.

  • To record all experiments in an accurate, timely and clearly presented manner, and use this to prepare data summaries and reports as and when required.

  • To contribute to the dissemination of scientific results by means of writing manuscripts for publication, and presenting at national and international meetings.

  • To liaise with scientific and clinical staff to maximize use and interpretation of genomic data to decipher cancer management strategies.

  • To provide expert bioinformatics and statistical support as directed by Dr. Marra.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Location: Vancouver, BC

Lab: Marra Lab

Posted: 2017-11-08

Closing Date: not stated

Contact: bcgscjobs@bcgsc.ca

 


Assistant Professor in Epigenetics of Chronic Childhood Disease | University of Manitoba

Applicants with strengths in epigenetics and childhood diseases, and expertise in bioinformatics are encouraged to apply to Position Number 24765. Candidates should hold an MD or PhD in a biological discipline with at least 3 years of relevant post-doctoral training. Candidates must show evidence of a history of research excellence, as evidenced by a strong publication record in high impact journals and the potential to secure competitive extramural peer reviewed grants; a history of mentoring; and a history of effective and productive collaboration. The position start date could be as early as February 15, 2018, or as negotiated.

Location: Winnipeg, MB

Department: Biochemistry and Medical Genetics, Max Rady College of Medicine

Posted: 2017-10-24

Closing Date: not stated

Contact: philip.dufresne@umanitoba.ca

 


PhD Student or Postdoctoral Researcher | McGill University

The candidate(s) will work on interdisciplinary projects on the role of diet in prostate cancer development. Projects will involve epigenomics, transcriptomics, and CRISPR screens articulated around multiple prostate cancer mouse models.

Location: Montreal, QC

Lab: Labbé Lab

Posted: 2017-10-24

Closing date: not stated

Contact: david.labbe@mcgill.ca

 


Postdoctoral Fellows | Princess Margaret Cancer Centre / University of Toronto

We seek postdoctoral fellows for several projects in computational genomics and machine learning. Selected projects include:

  1. Integrating epigenomic and sequence data to better understand human gene regulation.
  2. Creating models of transcription factor binding that allow us to predict the effects of perturbations.
  3. Developing deep learning techniques to find novel behavior in multiple functional genomics datasets.

We also welcome your project ideas! The project should concern mammalian epigenomics. Cancer relevance preferred.

Location: Toronto, ON

Lab: Hoffman Lab

Posted: 2017-09-25

Closing Date: not stated

Contact: join@hoffmanlab.org

 


Computational Postdoc | Princess Margaret Cancer Centre / University of Toronto

A computational postdoc position in epigenetics / epigenomics is available.

The Lupien Lab offers a multi-disciplinary team setting. The lab brings together enthusiastic scientists with diverse backgrounds, providing a wide range of perspectives to each research project. Our research focuses on identifying the molecular biology underlying cancer initiation and progression by exploiting the power of functional epigenomics.

Location: Toronto, ON

Lab: Lupien Lab

Posted: 2017-09-18

Closing Date: not stated

Contact: mlupien@uhnres.utoronto.ca