Canadian epigenetics jobs and training opportunities

If you have a Canadian job or training opportunity you'd like to list on this site and/or on our Twitter feed, please contact us at info@epigenomes.ca. This is a free service.

For international epigenetics and epigenomics job listings, please see the IHEC website.

 

Post-doctoral Fellowship in Cancer Epigenomics | University of British Columbia

We are seeking an innovative postdoctoral fellow who is interested in applying his/her expertise towards understanding the role of epigenetic dysfunction in human disease. The successful candidate will be embedded within a team of experimental and computational biologists and have access to a state-of-the-science epigenomic mapping pipeline and epigenomic datasets from primary cancer types and models. As part of national and international cancer research initiatives, s/he will direct a research program to uncover the pathogenic mechanisms underlying recurrent genetic lesions in specific cancer types with an ultimate goal of identifying and testing therapeutic targets.

To learn more about research in the Hirst Lab, please visit: http://hirstlab.msl.ubc.ca/ 

To learn more about pursuing a postdoctoral fellowship at the University of British Columbia, please visit: https://www.postdocs.ubc.ca

Qualifications: Exceptional recent PhD graduates with expertise in functional genomics and a desire to build a world-class independent research program are encouraged to apply

How to apply: Please  send CV and cover letter outlining career goals to swang@bcgsc.ca

Location: Vancouver, BC

Lab: Hirst Lab

Posted: 2018-11-13

Closing Date: not stated

Contact:  swang@bcgsc.ca

 

Graduate Students in Cancer Epigenomics | University of British Columbia

We are looking for innovative students who are interested in pursuing a PhD in the Epigenomics Laboratory at the University of British Columbia. Our research applies cutting edge experimental and computational methodologies to develop and test hypothesis of functional genomic mechanisms driving rare and common forms of cancer. The successful candidate will be embedded within a team of experimental and computational biologists and have access to a state-of-the-science epigenomic mapping pipeline and epigenomic datasets from primary cancer types and models. The applicant will be expected to work independently and collaboratively with clinical and other domain experts with an ultimate goal of improving outcomes for cancer patients. Students can choose from either a combined experimental and computational program or an exclusively computational track.

To learn more about research in the Hirst Lab, please visit: http://hirstlab.msl.ubc.ca/ 

To learn more about pursuing a PhD degree at the University of British Columbia, please visit: https://www.grad.ubc.ca

Qualifications: Exceptional students with demonstrated communication skills and undergraduate research experience. Students seeking an exclusively computational PhD must have unix shell scripting and statistical training.

How to apply: Please  send CV and cover letter outlining career goals to swang@bcgsc.ca

Location: Vancouver, BC

Lab: Hirst Lab

Posted: 2018-11-13

Closing Date: not stated

Contact:  swang@bcgsc.ca

 

Graduate studies in gene expression regulation, Robert lab in the IRCM, a research center affiliated with Université de Montréal

Research topic:

Building a high-resolution map of protein interactions along the RNA polymerase II CTD using site-specific BPA crosslinking in living cells

Project summary:

RNA polymerase II, the enzyme responsible for the transcription of pre-mRNA and most non-coding RNAs in eukaryotes, contains a carboxy-terminal domain (CTD) made of repetitions of a heptapeptide having YSPTSPS as consensus sequence. This peptide is repeated 26 times in yeast and 52 times in human. The tyrosine (Tyr1), threonine (Thr4) and all three serines (Ser2, 5 and 7) of each repetition are subject to a cycle of phosphorylation and dephosphorylation during transcription, creating an astronomical number of possible combinatorial phosphorylation states that are thought to constitute a “CTD code” read by CTD-binding proteins. Long-standing questions in the field are whether individual repeats have specific functions and whether the “CTD proteome” assembles in an organized structure or consists of very dynamic low affinity and high valency interactions? In this project, we propose to use BPA crosslinking to create a high-resolution map of protein binding along the CTD in living cells as a way to molecularly decipher the functions of different CTD repeats or regions.

Summary of responsibilities:
This project takes advantage of clever manipulations of the genetic code in Saccharomyces cerevisiae to introduce a modified amino acid (BPA) that can be induced to crosslink neighboring proteins in specific regions of the CTD in living cells. This approach will be used in combination with state-of-the-art proteomic technologies and standard biochemistry and molecular biology methods. The student/postdoc will be in charge of executing and analysing the vast majority of the experiments for the project and will be assisted during his/her training by Dr. Robert and senior members of the lab. The IRCM has several core laboratories with expertise that will enhance the training experience of the candidate.

Recent selected publications:

  • Collin P, Jeronimo C, Poitras C, Robert F. (2018) RNA Polymerase II CTD Tyrosine 1 is Required for Efficient Termination by the Nrd1-Nab3-Sen1 Pathway. Under review.
  • Jeronimo C, Collin P, Robert F. (2016) The RNA Polymerase II CTD: The Increasing Complexity of a Low-Complexity Protein Domain. J Mol Biol. 2016 Jun 19;428(12):2607-2622.
  • Bataille AR, Jeronimo C, Jacques PÉ, Laramée L, Fortin MÈ, Forest A, Bergeron M, Hanes SD, Robert F. (2012) A universal RNA polymerase II CTD cycle is orchestrated by complex interplays between kinase, phosphatase, and isomerase enzymes along genes. Mol Cell. 2012 Jan 27;45(2):158-70.

Job requirements:
We seek a highly motivated individual with a genuine interest in understanding the mechanistic aspects of molecular processes. A background in molecular biology and/or biochemistry is mandatory. Knowledge in bioinformatics, computer programming or statistics are assets but not mandatory. Only candidates with very good academic track records will be considered.

Location: Montreal, QC. At IRCM, a research center affiliated with Université de Montréal. Laboratory of Chromatin and Genomic Expression, led by Dr. François Robert. www.robertlab.org

Posted: 2018-10-31

Starting date: As soon as possible

Closing date: not stated

Contact: Send your candidacy by e-mail to: Francois Robert. francois.robert@ircm.qc.ca

 

Graduate studies in gene expression regulation, Robert lab in the IRCM, a research center affiliated with Université de Montréal

Research topic:

The use of long-read sequencing for the identification of protein complexes footprints on the chromatin of individual cells

Project summary:

Binding of proteins to specific sites on DNA is a fundamental aspect of nuclear processes such as gene expression, DNA replication, DNA repair and others. A number of techniques such as ChIP-seq, DNase-seq, FAIRE-seq and others are used to map protein-DNA interactions at the genome-wide scale in living cells. The readout of these methods, however, comes from averaging bulk measurements from a population of cells. These methods are therefore unable to reveal the cell-to-cell heterogeneity of protein-DNA interactions and provide very limited information about the relationship between neighboring interactions on the same molecule. The primary goal of the proposed project is to overcome the above-mentioned limitations by developing an advanced technique to generate high-resolution long footprints of protein-DNA binding at single-molecule level in living cells. The methods to be developed will take advantage of a recent sequencing technique called SMRT-sequencing from PacBio.

Summary of responsibilities:
This project combines the use of state-of-the-art functional genomic technologies with standard biochemistry and molecular biology in Saccharomyces cerevisiae. The student/postdoc will be in charge of executing and analysing the vast majority of the experiments for the project and will be assisted during his/her training by Dr. Robert and senior members of the lab. The IRCM has several core laboratories with expertise that will enhance the training experience of the candidate.

Recent selected publications:

  • Uwimana N, Collin P, Jeronimo C, Haibe-Kains B, Robert F. (2017) Bidirectional terminators in Saccharomyces cerevisiae prevent cryptic transcription from invading neighboring genes. Nucleic Acids Res. 2017 Jun 20;45(11):6417-6426.
  • Jeronimo C, Langelier M-F, Bataille AR, Pascal JM, Pugh BF, Robert F. (2016) Tail and Kinase modules differently regulate core Mediator recruitment and function in vivo. Mol Cell. 2016 Nov 3;64(3):455-466. doi: 10.1016/j.molcel.2016.09.002. Epub 2016 Oct 20.
  • Jeronimo C, Watanabe S, Kaplan CD, Peterson CL, Robert F. (2015) The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic Locations. Mol Cell. 2015 Jun 18;58(6):1113-23.

Job requirements:
We seek a highly motivated individual with a genuine interest in understanding the mechanistic aspects of molecular processes. A background in molecular biology and/or biochemistry is mandatory. Knowledge in bioinformatics, computer programming or statistics are assets but not mandatory. Only candidates with very good academic track records will be considered.

Location: Montreal, QC. At IRCM, a research center affiliated with Université de Montréal. Laboratory of Chromatin and Genomic Expression, led by Dr. François Robert. www.robertlab.org 

Posted: 2018-10-31

Starting date: As soon as possible

Closing date: not stated

Contact: Send your candidacy by e-mail to: Francois Robert. francois.robert@ircm.qc.ca

 

Postdoctoral Research Fellow in the Jabado lab, Research Institute of the McGill University Health Centre

A full-time position for a postdoctoral fellow is available in the research laboratory of Dr. Nada Jabado, at the Research Institute of McGill University Health Centre in Montreal, Canada. Research in the Jabado lab focuses on the investigation of pediatric brain tumours, specifically high-grade gliomas that are epigenetically dysregulated, such as those carrying histone 3 mutations. The lab uses diverse approaches to this end, including the genomic and epigenomic profiling of patient tumours, mouse xenografts and transgenic models, cell culture studies on primary and manipulated cell lines and drug studies on mouse models and cultured cells to test potential treatment agents. We use many state-of-the-art genomic/epigenomic techniques, such as ChIP-seq, Hi-C and single-cell RNA-seq, in addition to routine molecular and cell biology techniques like PCR, cloning and Western Blots. Dr. Jabado has numerous collaborations with research groups across the world that allow us to gain access to other specialized techniques. For more information on the Jabado lab, please visit our website at https://www.jabadolab.com/.

Applicants must have a PhD in a relevant life sciences field with experience in cell and molecular biology techniques including tissue culture. Experience in CRISPR/Cas9 genome editing and epigenomic techniques such as ChIP-seq is highly desirable. Bioinformatics skills required for analyzing genomic and epigenomic data would be a great asset. Ideally, the successful candidate will have the ability to straddle the wet-bench and bioinformatics components of work conducted in the Jabado lab, however candidates with experience in either may apply. Above all, we are looking for someone curious, highly independent and eager to use research to help improve the currently bleak prospects of children with high-grade pediatric brain tumours.

To apply, please send your CV and a cover letter to: njabadolab at gmail dot com

Location: The Research Institute of McGill University Health Centre in Montreal, QC.

Posted: 2018-10-15

Closing date: not stated

Contact: njabadolab at gmail dot com

 

Bioinformatics Scientist - The Children's Hospital Research Institute of Manitoba

The successful candidate will provide bioinformatics service for a multidisciplinary team of scientists. The work will apply bioinformatics data analysis under the supervision of a Scientific Oversight Committee. The work will focus on research questions relevant to maternal and child health that involves providing bioinformatics support to multidisciplinary researchers ranging from senior clinical scientists and basic biomedical scientists to the graduate and post-graduate trainees. The candidate will consult with and train researchers on the development of bioinformatics methods and data analysis pipelines to process large datasets from Next Generation Sequencing, proteomics and metabolomics and assist in the biological interpretation of the data.

The Department of Pediatrics and Child Health is one of Manitoba’s largest academic clinical departments, with diverse and significant commitment to excellence in clinical, basic and translational research, post-graduate clinical and research training, and graduate student training. Support for research and research training are facilitated through close partnership with the Children’s Hospital Research Institute of Manitoba (CHRIM), as well as with academic departments in the Rady Faculty of Health Sciences with programs accredited by the Faculty of Graduate Studies. CHRIM provides, within 32,000ft2 of new wet lab and animal research space, laboratory and office space for investigators and their team, multi-user research infrastructure and core facilities for cell and molecular biology research, as well as small animal lung function and metabolic testing. CHRIM has a substantial annual equipment budget and is home to a sophisticated Next Generation Sequencing core facility.

Responsibilities

  • Data quality check and data normalization
  • Data annotation and pathway analyses
  • Assist in developing, devising or improving existing bioinformatics methods, practices and procedures
  • The individual should be capable to work with human and animal model data
  • The individual will also be responsible for the integration of these large data sets for systems biology level of “mixomics” analyses

Candidates must have:

  • MSc or higher with experience in health related research required

Experience

  • Candidates should have a strong background in bioinformatics or computational biology, and be capable of conducting a range of statistical analyses
  • A strong background with unix/linux tools and administration is required
  • Previous experience with the analysis of large data sets in a health related field (e.g. proteomics, metabolomics or NGS) is mandatory
  • Advance knowledge of relevant platforms and data types (e.g. FASTQ, BAM, VCF, MAF) and related analytical tools is necessary
  • Experience with coding as well as machine learning approaches in R are an asset

Skills & Abilities

  • Ability to work independently and within a dynamic collaborative and multidisciplinary environment
  • Possess excellent communication and organizational skills
  • Ability to meet deadlines and milestones
  • Have a proven track record of productivity
  • Familiarity with biology, molecular biology and computer hardware is an asset
  • Assist in developing, devising or improving existing bioinformatics methods, practices and procedures

Applications should be sent by email to humanresources@chrim.ca

Location: The Children’s Hospital Research Institute of Manitoba, Winnipeg, MB

Posted: 2018-09-13

Closing date: not stated

Contact: humanresources@chrim.ca

 

Postdoctoral Fellow/Research Associate - Hoodless Lab: Vancouver, Canada

A postdoctoral fellowship/research associate position is available in the Hoodless lab based in the BC Cancer Agency Research Centre in Vancouver, Canada. The ideal candidate will have expertise in mouse genetic modelling, embryology, hepatic biology and/or transcription/epigenetics. Candidates must hold a doctoral degree in a relevant field, be looking for a collaborative and dynamic environment, and have a track record of productivity.

The Hoodless lab uses state of the art genomic technologies to explore and gain new insight into classical processes in developmental biology. Using genome-wide analysis of gene expression, transcription factor binding and histone modifications, they investigate regulatory mechanisms in heart and gastrointestinal tract development in the mouse embryo. Experience with bioinformatics approaches to biological data and familiarity with handling of genomics data will be an advantage.

Interested candidates should send a statement of research interest, curriculum vitae and contact details for 3 referees to:

Jordan Cran (jcran@bccrc.ca) with the subject: Postdoctoral Fellow/Research Associate - Hoodless Lab

Location: Vancouver, BC

Lab: Hoodless Lab (link: http://www.terryfoxlab.ca/people-detail/pamela-hoodless/)

Posted: 2018-08-10

Closing date: 2018-10-31

Contact: jcran@bccrc.ca

 

Postdoctoral fellow applied to functional epigenomics : Toronto, Canada

Fully affiliated with the University of Toronto and home to members of the Faculties of Medicine, The Princess Margaret Cancer Centre is part of one of Canada's largest hospital-based research centers. As one of the top five cancer research institutes in North America The Princess Margaret Cancer Centre fosters a rich academic and collegial environment. Combining research excellence with state-of-the-art infrastructure, The Princess Margaret Cancer Centre is investing heavily in strategic research platforms and has developed research capacity in areas such as Epigenomics, Genomics, Proteomics, Clinical Technologies, and Clinical Studies to drive investigations into human biology and health care now and into the future.

As part of The Princess Margaret Cancer Centre Epigenomics program and affiliated with the Ontario Institute for Cancer Research (OICR), Dr. Mathieu Lupien is currently seeking applications for a wet lab and computational postdoctoral fellows applied to functional epigenomics. The work will focus on defining the interplay between epigenomics, metabolomics and/or transcriptional regulation in cancer (breast, prostate or brain (GBM)). The successful candidate will be involved in the generation of omics data (ChIP-seq, ATAC-seq, RNA-seq, whole-genome-seq, etc) and their analysis. More information on research interests and publications from the Lupien lab is available at: www.pmgenomics.ca/lupienlab

Candidates should have a strong background in epigenetics, genomics, metabolomics, computational biology, bioinformatics or biostatistics, hold a doctoral degree in a relevant field, be looking for a collaborative and dynamic environment, and have a track record of productivity and innovation. Prior experience in generating and analyzing omics datasets is an asset but not a requirement. The salary of this yearly renewable position will be established according to institutional guidelines.

Please forward current curriculum vitae including a publication list and names of three references to: mlupien@uhnres.utoronto.ca

We thank all applicants for applying, however, only those selected for an interview will be contacted.

Location: Toronto, ON

Lab: Lupien Lab

Posted: 2018-05-25

Closing Date: 2018-07-01

Contact:  mlupien@uhnres.utoronto.ca

 

Post-doctoral Fellowship in Brain Cancer Epigenomics | University of Calgary

 We are looking for a talented, hard-working, independent and highly motivated individual to join us as a postdoctoral fellow.

The candidate needs to be within one year of their PhD, and have a proven record of peer-reviewed research publications. Experience with molecular techniques and cell culture models is a requirement. Previous work with animal models is preferable.

The successful candidate will have an opportunity to study chromatin biology in the context of brain tumors. She/he will use patient-derived primary cultures and patient-derived xenografts to study molecular determinants of cancer stem cell properties. Single-cell RNA-seq, genomics and epigenomics techniques will be complemented by functional studies of gene function in vitro and in vivo.

Please note that this is a wet lab position, but the successful candidate will have an opportunity to implement computational pipelines that have been standardized in the lab if she/he is so inclined. Computational experience is NOT a requirement for this position.

We have a very competitive salary and benefit package. And the Rockies are less than an hour away, making Calgary a perfect place for the scientist that needs to be immersed in nature to think!

If you are interested in joining us, please email your CV and a cover letter to marco.gallo@ucalgary.ca

Location: Calgary, AB

Lab: Gallo Lab

Posted: 2018-03-09

Closing Date: not stated

Contact:  marco.gallo@ucalgary.ca

 

Bioinformatics Postdoctoral Fellow and Bioinformatics Research Associate | Princess Margaret Cancer Centre

Two funded positions are available in the De Carvalho Lab at Princess Margaret Cancer Centre: Bioinformatics Postdoctoral Fellow and Bioinformatics Research Associate

The focus of the projects are in translational cancer epigenomics, with multiple projects available in Methylome profiling of cancer cells and circulating cell-free DNA ('liquid biopsy') for cancer classification, early detection and disease monitoring; Cancer Epigenetics therapy to target cancer stem cells and to increase anti-tumour immune response. The projects will include epigenomic approachers such as ChIP-seq, ATAC-seq, CUT&RUN, RRBS, WGBS among others and functional approaches such as CRISPR screening.

The research will be conducted at the Princess Margaret Cancer Centre, a research hospital affiliated to the University of Toronto, in one of the most liveable cities in the world.

The ideal candidate should have:

  • PhD in computational biology, bioinformatics, biostatistics, cancer biology, epigenomics, genomics, or a related field;

  • Experience with epigenomics and transcriptomics data analysis from ChIP-seq, ATAC-seq, RRBS, WGBS, RNA-seq experiments;

  • Experience with large data-sets (e.g., ENCODE, TCGA, GTEx);

  • Experience with Machine Learning/Deep Learning applied to biology or oncology;

  • Proficiency in general-purpose programming language and scientific data processing ecosystems (e.g. R, R-studio);

  • Good publication record

Location: Toronto, ON

Lab: De Carvalho Lab

Posted: 2018-01-03

Closing Date: not stated

Contact: Those interested in the position described should submit full CV and cover letter to Dr. Daniel D. De Carvalho: epigenome.search@gmail.com

 

Bioinformatician | BC Cancer Agency, Canada's Michael Smith Genome Sciences Centre

We are seeking an enthusiastic and self-motivated bioinformatician, with excellent communication skills, to work on integrative and comprehensive analyses of cancer genome/transcriptome/epigenome sequence data. The successful applicant will have a proven track record of publications in scientific journals, be fluent in R and at least one of the following programming languages: Perl/Python/C++/Java, and is expected to have strong skills in the field of one or more of the following: genomics, cancer biology and statistics. Knowledge of and experience with large-scale cancer genome data sets (such as TCGA) is particularly desired. A PhD or equivalent is desirable, although qualified applicants with a research-based masters degree may be considered.

The successful applicant for this position will be based within the laboratory of Dr. Marco Marra in Canada's Michael Smith Genome Sciences Centre (GSC) at the BC Cancer Agency. Dr. Marra is the director of the GSC, a world-class genome institute that generates sequence data for hundreds of cancer samples each year, and has state-of-the-art computational power, including a 8000 node computing cluster and >10 large CPU and RAM machines for data analysis. As such, the successful applicant will have the opportunity to mine large scale cancer genome data sets to address pertinent questions concerning cancer pathogenesis and treatment resistance in adults and children. 

The Marra Lab is a successful multi-disciplinary team of cancer researchers, and is filled with passionate and determined individuals who will provide the successful candidate with a stimulating and conducive environment to participate and grow as a scientist. The research in the lab is conducted in close collaboration with local and international scientists and clinicians, and thus will also provide the successful candidate with opportunities to learn from a large network of talented professionals.

Main Duties and Responsibilities

  • To survey the relevant literature to identify pertinent scientific questions to be addressed, and relevant techniques to employ for this purpose.

  • To apply state-of-the-art bioinformatics methods to the analysis of cancer sequence data.

  • To record all experiments in an accurate, timely and clearly presented manner, and use this to prepare data summaries and reports as and when required.

  • To contribute to the dissemination of scientific results by means of writing manuscripts for publication, and presenting at national and international meetings.

  • To liaise with scientific and clinical staff to maximize use and interpretation of genomic data to decipher cancer management strategies.

  • To provide expert bioinformatics and statistical support as directed by Dr. Marra.

All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Location: Vancouver, BC

Lab: Marra Lab

Posted: 2017-11-08

Closing Date: not stated

Contact: bcgscjobs@bcgsc.ca

 

Assistant Professor in Epigenetics of Chronic Childhood Disease | University of Manitoba

Applicants with strengths in epigenetics and childhood diseases, and expertise in bioinformatics are encouraged to apply to Position Number 24765. Candidates should hold an MD or PhD in a biological discipline with at least 3 years of relevant post-doctoral training. Candidates must show evidence of a history of research excellence, as evidenced by a strong publication record in high impact journals and the potential to secure competitive extramural peer reviewed grants; a history of mentoring; and a history of effective and productive collaboration. The position start date could be as early as February 15, 2018, or as negotiated.

Location: Winnipeg, MB

Department: Biochemistry and Medical Genetics, Max Rady College of Medicine

Posted: 2017-10-24

Closing Date: not stated

Contact: philip.dufresne@umanitoba.ca

 

PhD Student or Postdoctoral Researcher | McGill University

The candidate(s) will work on interdisciplinary projects on the role of diet in prostate cancer development. Projects will involve epigenomics, transcriptomics, and CRISPR screens articulated around multiple prostate cancer mouse models.

Location: Montreal, QC

Lab: Labbé Lab

Posted: 2017-10-24

Closing date: not stated

Contact: david.labbe@mcgill.ca

 

Postdoctoral Fellows | Princess Margaret Cancer Centre / University of Toronto

We seek postdoctoral fellows for several projects in computational genomics and machine learning. Selected projects include:

  1. Integrating epigenomic and sequence data to better understand human gene regulation.
  2. Creating models of transcription factor binding that allow us to predict the effects of perturbations.
  3. Developing deep learning techniques to find novel behavior in multiple functional genomics datasets.

We also welcome your project ideas! The project should concern mammalian epigenomics. Cancer relevance preferred.

Location: Toronto, ON

Lab: Hoffman Lab

Posted: 2017-09-25

Closing Date: not stated

Contact: join@hoffmanlab.org

 

Computational Postdoc | Princess Margaret Cancer Centre / University of Toronto

A computational postdoc position in epigenetics / epigenomics is available.

The Lupien Lab offers a multi-disciplinary team setting. The lab brings together enthusiastic scientists with diverse backgrounds, providing a wide range of perspectives to each research project. Our research focuses on identifying the molecular biology underlying cancer initiation and progression by exploiting the power of functional epigenomics.

Location: Toronto, ON

Lab: Lupien Lab

Posted: 2017-09-18

Closing Date: not stated

Contact: mlupien@uhnres.utoronto.ca